.Attributes Medicine, Published online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic reviews revealed that a novel reassortant viral lineage of the Oropouche virus, which has been flowing in the western side Amazon.com area of Brazil for concerning a years, is actually related to the current human outbreaks between 2022 as well as 2024.